Quinidine                package:nlme                R Documentation

_Q_u_i_n_i_d_i_n_e _K_i_n_e_t_i_c_s

_D_e_s_c_r_i_p_t_i_o_n:

     The `Quinidine' data frame has 1471 rows and 14 columns.

_F_o_r_m_a_t:

     This data frame contains the following columns:

     _S_u_b_j_e_c_t a factor identifying the patient on whom the data were
            collected.

     _t_i_m_e a numeric vector giving the time (hr) at which the drug was
            administered or the blood sample drawn.  This is measured
            from the time the patient entered the study.

     _c_o_n_c a numeric vector giving the serum quinidine concentration
            (mg/L).

     _d_o_s_e a numeric vector giving the dose of drug administered (mg).
            Although there were two different forms of quinidine
            administered, the doses were adjusted for differences in
            salt content by conversion to milligrams of quinidine base.

     _i_n_t_e_r_v_a_l a numeric vector giving the when the drug has been given
            at regular intervals for a sufficiently long period of time
            to assume steady state behavior, the interval is recorded.

     _A_g_e a numeric vector giving the age of the subject on entry to the
            study (yr).

     _H_e_i_g_h_t a numeric vector giving the height of the subject on entry
            to the study (in.).

     _W_e_i_g_h_t a numeric vector giving the body weight of the subject
            (kg).

     _R_a_c_e a factor with levels `Caucasian',  `Latin', and `Black'
            identifying the race of the subject.

     _S_m_o_k_e a factor with levels `no' and `yes' giving smoking status at
            the time of the measurement.

     _E_t_h_a_n_o_l a factor with levels `none',  `current', `former' giving
            ethanol (alcohol) abuse status at the time of the
            measurement.

     _H_e_a_r_t a factor with levels `No/Mild',  `Moderate', and  `Severe'
            indicating congestive heart failure for the subject.

     _C_r_e_a_t_i_n_i_n_e an ordered factor with levels `< 50' < `>= 50'
            indicating the creatine clearance (mg/min).

     _g_l_y_c_o a numeric vector giving the alpha-1 acid glycoprotein
            concentration (mg/dL).  Often measured at the same time as
            the quinidine concentration.

_D_e_t_a_i_l_s:

     Verme et al. (1992) analyze routine clinical data on patients
     receiving the drug quinidine as a treatment for cardiac arrythmia
     (atrial fibrillation of ventricular arrythmias).  All patients
     were receiving oral quinidine doses.  At irregular intervals blood
     samples were drawn and serum concentrations of quinidine were
     determined.  These data are analyzed in several publications,
     including Davidian and Giltinan (1995, section 9.3).

_S_o_u_r_c_e:

     Pinheiro, J. C. and Bates, D. M. (2000), Mixed-Effects Models in S
     and S-PLUS, Springer, New York.  (Appendix A.25)

     Davidian, M. and Giltinan, D. M. (1995), Nonlinear Models for
     Repeated Measurement Data,  Chapman and Hall, London.

     Verme, C. N., Ludden,  T. M., Clementi, W. A. and Harris, S. C.
     (1992), Pharmacokinetics of quinidine in male patients: A
     population analysis, Clinical Pharmacokinetics, 22, 468-480.

_E_x_a_m_p_l_e_s:

     data(Quinidine)

